The Cosmic Dawn and Reionization epochs remain a fundamental but challenging frontier of astrophysics and cosmology. We advocate a large-scale, multi-tracer approach to develop a comprehensive understanding of the physics that led to the formation and evolution of the first stars and galaxies. We highlight the line intensity mapping technique to trace the multi-phase reionization topology on large scales, and measure reionization history in detail. Besides 21cm, we advocate for Lya tomography mapping during the epoch of Wouthuysen-Field coupling as an additional probe of the cosmic dawn era.