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Register a new userCross-Modal Data Programming Enables Rapid Medical Machine Learning
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Labeling training datasets has become a key barrier to building medical machine learning models. One strategy is to generate training labels programmatically, for example by applying natural language processing pipelines to text reports associated with imaging studies. We propose cross-modal data programming, which generalizes this intuitive strategy in a theoretically-grounded way that enables simpler, clinician-driven input, reduces required labeling time, and improves with additional unlabeled data. In this approach, clinicians generate training labels for models defined over a target modality (e.g. images or time series) by writing rules over an auxiliary modality (e.g. text reports). The resulting technical challenge consists of estimating the accuracies and correlations of these rules; we extend a recent unsupervised generative modeling technique to handle this cross-modal setting in a provably consistent way. Across four applications in radiography, computed tomography, and electroencephalography, and using only several hours of clinician time, our approach matches or exceeds the efficacy of physician-months of hand-labeling with statistical significance, demonstrating a fundamentally faster and more flexible way of building machine learning models in medicine.
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We present SmartChoices, an approach to making machine learning (ML) a first class citizen in programming languages which we see as one way to lower the entrance cost to applying ML to problems in new domains. There is a growing divide in approaches to building systems: on the one hand, programming leverages human experts to define a system while on the other hand behavior is learned from data in machine learning. We propose to hybridize these two by providing a 3-call API which we expose through an object called SmartChoice. We describe the SmartChoices-interface, how it can be used in programming with minimal code changes, and demonstrate that it is an easy to use but still powerful tool by demonstrating improvements over not using ML at all on three algorithmic problems: binary search, QuickSort, and caches. In these three examples, we replace the commonly used heuristics with an ML model entirely encapsulated within a SmartChoice and thus requiring minimal code changes. As opposed to previous work applying ML to algorithmic problems, our proposed approach does not require to drop existing implementations but seamlessly integrates into the standard software development workflow and gives full control to the software developer over how ML methods are applied. Our implementation relies on standard Reinforcement Learning (RL) methods. To learn faster, we use the heuristic function, which they are replacing, as an initial function. We show how this initial function can be used to speed up and stabilize learning while providing a safety net that prevents performance to become substantially worse -- allowing for a safe deployment in critical applications in real life.
This paper reviews recent advances in the field of optimization under uncertainty via a modern data lens, highlights key research challenges and promise of data-driven optimization that organically integrates machine learning and mathematical programming for decision-making under uncertainty, and identifies potential research opportunities. A brief review of classical mathematical programming techniques for hedging against uncertainty is first presented, along with their wide spectrum of applications in Process Systems Engineering. A comprehensive review and classification of the relevant publications on data-driven distributionally robust optimization, data-driven chance constrained program, data-driven robust optimization, and data-driven scenario-based optimization is then presented. This paper also identifies fertile avenues for future research that focuses on a closed-loop data-driven optimization framework, which allows the feedback from mathematical programming to machine learning, as well as scenario-based optimization leveraging the power of deep learning techniques. Perspectives on online learning-based data-driven multistage optimization with a learning-while-optimizing scheme is presented.
In this study, we propose a machine-learning-based approach to identify the modal parameters of the output-only data for structural health monitoring (SHM) that makes full use of the characteristic of independence of modal responses and the principle of machine learning. By taking advantage of the independence feature of each mode, we use the principle of unsupervised learning, making the training process of the deep neural network becomes the process of modal separation. A self-coding deep neural network is designed to identify the structural modal parameters from the vibration data of structures. The mixture signals, that is, the structural response data, are used as the input of the neural network. Then we use a complex loss function to restrict the training process of the neural network, making the output of the third layer the modal responses we want, and the weights of the last two layers are mode shapes. The deep neural network is essentially a nonlinear objective function optimization problem. A novel loss function is proposed to constrain the independent feature with consideration of uncorrelation and non-Gaussianity to restrict the designed neural network to obtain the structural modal parameters. A numerical example of a simple structure and an example of actual SHM data from a cable-stayed bridge are presented to illustrate the modal parameter identification ability of the proposed approach. The results show the approachs good capability in blindly extracting modal information from system responses.
Explainable machine learning has become increasingly prevalent, especially in healthcare where explainable models are vital for ethical and trusted automated decision making. Work on the susceptibility of deep learning models to adversarial attacks has shown the ease of designing samples to mislead a model into making incorrect predictions. In this work, we propose a model agnostic explainability-based method for the accurate detection of adversarial samples on two datasets with different complexity and properties: Electronic Health Record (EHR) and chest X-ray (CXR) data. On the MIMIC-III and Henan-Renmin EHR datasets, we report a detection accuracy of 77% against the Longitudinal Adversarial Attack. On the MIMIC-CXR dataset, we achieve an accuracy of 88%; significantly improving on the state of the art of adversarial detection in both datasets by over 10% in all settings. We propose an anomaly detection based method using explainability techniques to detect adversarial samples which is able to generalise to different attack methods without a need for retraining.
In this paper we study the problem of learning from multiple modal data for purpose of document classification. In this problem, each document is composed two different modals of data, i.e., an image and a text. Cross-modal factor analysis (CFA) has been proposed to project the two different modals of data to a shared data space, so that the classification of a image or a text can be performed directly in this space. A disadvantage of CFA is that it has ignored the supervision information. In this paper, we improve CFA by incorporating the supervision information to represent and classify both image and text modals of documents. We project both image and text data to a shared data space by factor analysis, and then train a class label predictor in the shared space to use the class label information. The factor analysis parameter and the predictor parameter are learned jointly by solving one single objective function. With this objective function, we minimize the distance between the projections of image and text of the same document, and the classification error of the projection measured by hinge loss function. The objective function is optimized by an alternate optimization strategy in an iterative algorithm. Experiments in two different multiple modal document data sets show the advantage of the proposed algorithm over other CFA methods.
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