The radiative and mechanical interaction of stars with their environment drives the evolution of the ISM and of galaxies as a whole. The far-IR emission (lambda ~30 to 350 microns) from atoms and molecules dominates the cooling of the warm gas in the neutral ISM, the material that ultimately forms stars. Far-IR lines are thus the most sensitive probes of stellar feedback processes, and allow us to quantify the deposition and cycling of energy in the ISM. While ALMA (in the (sub)mm) and JWST (in the IR) provide astonishing sub-arcsecond resolution images of point sources and their immediate environment, they cannot access the main interstellar gas coolants, nor are they designed to image entire star-forming regions (SFRs). Herschel far-IR photometric images of the interstellar dust thermal emission revealed the ubiquitous large-scale filamentary structure of SFRs, their mass content, and the location of thousands of prestellar cores and protostars. These images, however, provide a static view of the ISM: not only they dont constrain the cloud dynamics, moreover they cannot reveal the chemical composition and energy transfer within the cloud, thus giving little insight into the regulation process of star formation by stellar feedback. In this white paper we emphasize the need of a space telescope with wide-field spectral-imaging capabilities in the critical far-IR domain.