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Atrial Scar Quantification via Multi-scale CNN in the Graph-cuts Framework

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 Added by Lei Li
 Publication date 2019
and research's language is English




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Late gadolinium enhancement magnetic resonance imaging (LGE MRI) appears to be a promising alternative for scar assessment in patients with atrial fibrillation (AF). Automating the quantification and analysis of atrial scars can be challenging due to the low image quality. In this work, we propose a fully automated method based on the graph-cuts framework, where the potentials of the graph are learned on a surface mesh of the left atrium (LA) using a multi-scale convolutional neural network (MS-CNN). For validation, we have employed fifty-eight images with manual delineations. MS-CNN, which can efficiently incorporate both the local and global texture information of the images, has been shown to evidently improve the segmentation accuracy of the proposed graph-cuts based method. The segmentation could be further improved when the contribution between the t-link and n-link weights of the graph is balanced. The proposed method achieves a mean accuracy of 0.856 +- 0.033 and mean Dice score of 0.702 +- 0.071 for LA scar quantification. Compared with the conventional methods, which are based on the manual delineation of LA for initialization, our method is fully automatic and has demonstrated significantly better Dice score and accuracy (p < 0.01). The method is promising and can be useful in diagnosis and prognosis of AF.

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An assumption widely used in recent neural style transfer methods is that image styles can be described by global statics of deep features like Gram or covariance matrices. Alternative approaches have represented styles by decomposing them into local pixel or neural patches. Despite the recent progress, most existing methods treat the semantic patterns of style image uniformly, resulting unpleasing results on complex styles. In this paper, we introduce a more flexible and general universal style transfer technique: multimodal style transfer (MST). MST explicitly considers the matching of semantic patterns in content and style images. Specifically, the style image features are clustered into sub-style components, which are matched with local content features under a graph cut formulation. A reconstruction network is trained to transfer each sub-style and render the final stylized result. We also generalize MST to improve some existing methods. Extensive experiments demonstrate the superior effectiveness, robustness, and flexibility of MST.
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