We investigate simultaneous estimation of multi-parameter quantum estimation with time-dependent Hamiltonians. We analytically obtain the maximal quantum Fisher information matrix for two-parameter in time-dependent three-level systems. The optimal coherent control scheme is proposed to increase the estimation precisions. In a example of a spin-1 particle in a uniformly rotating magnetic field, the optimal coherent Hamiltonians for different parameters can be chosen to be completely same. However, in general, the optimal coherent Hamiltonians for different parameters are incompatibility. In this situation, we suggest a variance method to obtain the optimal coherent Hamiltonian for estimating multiple parameters simultaneously, and obtain the optimal simultaneous estimation precision of two-parameter in a three-level Landau-Zener Hamiltonian.
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