We present the color and flux variability analysis at 3.4 {mu}m (W1-band) and 4.6 {mu}m (W 2-band) of 492 narrow-line Seyfert 1 (NLSy1) galaxies using archival data from the Wide-field Infrared Survey Explorer (WISE). In the WISE color-color, (W1 - W2) versus (W2 - W3) diagram, ~58% of the NLSy1 galaxies of our sample lie in the region occupied by the blazar category of active galactic nuclei (AGN). The mean W1 - W2 color of candidate variable NLSy1 galaxies is $0.99 pm 0.18$ mag. The average amplitude of variability is $0.11 pm 0.07$ mag in long-term (multi-year) with no difference in variability between W1 and W2-bands. The W1 - W2 color of NLSy1 galaxies is anti-correlated with the relative strength of [O III] to H{beta}, strongly correlated with continuum luminosity, black hole mass, and Eddington ratio. The long-term amplitude of variability shows weak anti-correlation with the Fe II strength, continuum luminosity and Eddington ratio. A positive correlation between color as well as the amplitude of variability with the radio power at 1.4 GHz was found for the radio-detected NLSy1 galaxies. This suggests non-thermal synchrotron contribution to the mid-infrared color and flux variability in radio-detected NLSy1 galaxies.
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