The isospin character of p-n pairs at large relative momentum has been observed for the first time in the 16O ground state. A strong population of the J,T=1,0 state and a very weak population of the J,T=0,1 state were observed in neutron pick up domain of 16O(p,pd) at 392 MeV. This strong isospin dependence at large momentum transfer is not reproduced by the distorted-wave impulse approximation calculations with known spectroscopic amplitudes. The results indicate the presence of high-momentum protons and neutrons induced by the tensor interactions in ground state of 16O.
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