In the work, the thermal and vacuum fluctuation is predicted capable of generating a Casimir thrust force on a rotating chiral particle, which will push or pull the particle along the rotation axis. The Casimir thrust force comes from two origins: i) the rotation-induced symmetry-breaking in the vacuum and thermal fluctuation and ii) the chiral cross-coupling between electric and magnetic fields and dipoles, which can convert the vacuum spin angular momentum (SAM) to the vacuum force. Using the fluctuation dissipation theorem (FDT), we derive the analytical expressions for the vacuum thrust force in dipolar approximation and the dependences of the force on rotation frequency, temperature and material optical properties are investigated. The work reveals a new mechanism to generate a vacuum force, which opens a new way to exploit zero-point energy of vacuum.