We report a state-of-the-art lattice calculation of the isovector quark transversity distribution of the proton at the physical pion mass. Within the framework of large-momentum effective theory (LaMET), we compute the transversity quasi-distributions using clover valence fermions on 2+1+1-flavor (up/down, strange, charm) HISQ-lattice configurations with boosted proton momenta as large as 3.0~GeV. The relevant lattice matrix elements are nonperturbatively renormalized in regularization-independent momentum-subtraction (RI/MOM) scheme and systematically matched to the physical transversity distribution. With high statistics, large proton momenta and meticulous control of excited-state contamination, we provide the best theoretical prediction for the large-$x$ isovector quark transversity distribution, with better precision than the most recent global analyses of experimental data. Our result also shows that the sea quark asymmetry in the proton transversity distribution is consistent with zero, which has been assumed in all current global analyses.
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