We describe a recent lattice-QCD calculation of the leptonic decay constants of heavy-light pseudoscalar mesons containing charm and bottom quarks and of the masses of the up, down, strange, charm, and bottom quarks. Results for these quantities are of the highest precision to date. Calculations use 24 isospin-symmetric ensembles of gauge-field configurations with six different lattice spacings as small as approximately 0.03 fm and several values of the light quark masses down to physical values of the average up- and down-sea-quark masses. We use the highly-improved staggered quark (HISQ) formulation for valence and sea quarks, including the bottom quark. The analysis employs heavy-quark effective theory (HQET). A novel HQET method is used in the determination of the quark masses.
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