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Register a new userSPULTRA: Low-Dose CT Image Reconstruction with Joint Statistical and Learned Image Models
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Added by
Siqi Ye
Publication date
2018
fields
Electronic Engineering
and research's language is
English
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Low-dose CT image reconstruction has been a popular research topic in recent years. A typical reconstruction method based on post-log measurements is called penalized weighted-least squares (PWLS). Due to the underlying limitations of the post-log statistical model, the PWLS reconstruction quality is often degraded in low-dose scans. This paper investigates a shifted-Poisson (SP) model based likelihood function that uses the pre-log raw measurements that better represents the measurement statistics, together with a data-driven regularizer exploiting a Union of Learned TRAnsforms (SPULTRA). Both the SP induced data-fidelity term and the regularizer in the proposed framework are nonconvex. The proposed SPULTRA algorithm uses quadratic surrogate functions for the SP induced data-fidelity term. Each iteration involves a quadratic subproblem for updating the image, and a sparse coding and clustering subproblem that has a closed-form solution. The SPULTRA algorithm has a similar computational cost per iteration as its recent counterpart PWLS-ULTRA that uses post-log measurements, and it provides better image reconstruction quality than PWLS-ULTRA, especially in low-dose scans.
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This paper applies the recent fast iterative neural network framework, Momentum-Net, using appropriate models to low-dose X-ray computed tomography (LDCT) image reconstruction. At each layer of the proposed Momentum-Net, the model-based image reconstruction module solves the majorized penalized weighted least-square problem, and the image refining module uses a four-layer convolutional neural network (CNN). Experimental results with the NIH AAPM-Mayo Clinic Low Dose CT Grand Challenge dataset show that the proposed Momentum-Net architecture significantly improves image reconstruction accuracy, compared to a state-of-the-art noniterative image denoising deep neural network (NN), WavResNet (in LDCT). We also investigated the spectral normalization technique that applies to image refining NN learning to satisfy the nonexpansive NN property; however, experimental results show that this does not improve the image reconstruction performance of Momentum-Net.
X-ray Computed Tomography (CT) is an important tool in medical imaging to obtain a direct visualization of patient anatomy. However, the x-ray radiation exposure leads to the concern of lifetime cancer risk. Low-dose CT scan can reduce the radiation exposure to patient while the image quality is usually degraded due to the appearance of noise and artifacts. Numerous studies have been conducted to regularize CT image for better image quality. Yet, exploring the underlying manifold where real CT images residing on is still an open problem. In this paper, we propose a fully data-driven manifold learning approach by incorporating the emerging deep-learning technology. An encoder-decoder convolutional neural network has been established to map a CT image to the inherent low-dimensional manifold, as well as to restore the CT image from its corresponding manifold representation. A novel reconstruction algorithm assisted by the leant manifold prior has been developed to achieve high quality low-dose CT reconstruction. In order to demonstrate the effectiveness of the proposed framework, network training, testing, and comprehensive simulation study have been performed using patient abdomen CT images. The trained encoder-decoder CNN is capable of restoring high-quality CT images with average error of ~20 HU. Furthermore, the proposed manifold prior assisted reconstruction scheme achieves high-quality low-dose CT reconstruction, with average reconstruction error of < 30 HU, more than five times and two times lower than that of filtered back projection method and total-variation based iterative reconstruction method, respectively.
Traditional model-based image reconstruction (MBIR) methods combine forward and noise models with simple object priors. Recent machine learning methods for image reconstruction typically involve supervised learning or unsupervised learning, both of which have their advantages and disadvantages. In this work, we propose a unified supervised-unsupervised (SUPER) learning framework for X-ray computed tomography (CT) image reconstruction. The proposed learning formulation combines both unsupervised learning-based priors (or even simple analytical priors) together with (supervised) deep network-based priors in a unified MBIR framework based on a fixed point iteration analysis. The proposed training algorithm is also an approximate scheme for a bilevel supervised training optimization problem, wherein the network-based regularizer in the lower-level MBIR problem is optimized using an upper-level reconstruction loss. The training problem is optimized by alternating between updating the network weights and iteratively updating the reconstructions based on those weights. We demonstrate the learned SUPER models efficacy for low-dose CT image reconstruction, for which we use the NIH AAPM Mayo Clinic Low Dose CT Grand Challenge dataset for training and testing. In our experiments, we studied different combinations of supervised deep network priors and unsupervised learning-based or analytical priors. Both numerical and visual results show the superiority of the proposed unified SUPER methods over standalone supervised learning-based methods, iterative MBIR methods, and variations of SUPER obtained via ablation studies. We also show that the proposed algorithm converges rapidly in practice.
The extensive use of medical CT has raised a public concern over the radiation dose to the patient. Reducing the radiation dose leads to increased CT image noise and artifacts, which can adversely affect not only the radiologists judgement but also the performance of downstream medical image analysis tasks. Various low-dose CT denoising methods, especially the recent deep learning based approaches, have produced impressive results. However, the existing denoising methods are all downstream-task-agnostic and neglect the diverse needs of the downstream applications. In this paper, we introduce a novel Task-Oriented Denoising Network (TOD-Net) with a task-oriented loss leveraging knowledge from the downstream tasks. Comprehensive empirical analysis shows that the task-oriented loss complements other task agnostic losses by steering the denoiser to enhance the image quality in the task related regions of interest. Such enhancement in turn brings general boosts on the performance of various methods for the downstream task. The presented work may shed light on the future development of context-aware image denoising methods.
Recent years have witnessed growing interest in machine learning-based models and techniques for low-dose X-ray CT (LDCT) imaging tasks. The methods can typically be categorized into supervised learning methods and unsupervised or model-based learning methods. Supervised learning methods have recently shown success in image restoration tasks. However, they often rely on large training sets. Model-based learning methods such as dictionary or transform learning do not require large or paired training sets and often have good generalization properties, since they learn general properties of CT image sets. Recent works have shown the promising reconstruction performance of methods such as PWLS-ULTRA that rely on clustering the underlying (reconstructed) image patches into a learned union of transforms. In this paper, we propose a new Supervised-UnsuPERvised (SUPER) reconstruction framework for LDCT image reconstruction that combines the benefits of supervised learning methods and (unsupervised) transform learning-based methods such as PWLS-ULTRA that involve highly image-adaptive clustering. The SUPER model consists of several layers, each of which includes a deep network learned in a supervised manner and an unsupervised iterative method that involves image-adaptive components. The SUPER reconstruction algorithms are learned in a greedy manner from training data. The proposed SUPER learning methods dramatically outperform both the constituent supervised learning-based networks and iterative algorithms for LDCT, and use much fewer iterations in the iterative reconstruction modules.
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