Using data samples collected by the BESIII detector operating at the BEPCII storage ring, we measure the $e^+e^- to K_{S}^{0}K^{pm}pi^{mp}$ Born cross sections at center-of-mass energies between 3.8 and 4.6,GeV, corresponding to a luminosity of about 5.0~fb$^{-1}$. The results are compatible with the BABAR measurements, but with the precision significantly improved. A simple $1/s^n$ dependence for the continuum process can describe the measured cross sections, but a better fit is obtained by an additional resonance near 4.2,GeV, which could be an excited charmonium or a charmonium-like state.