Measurement-device-independent quantum key distribution (MDI-QKD) can eliminate all detector side channels and it is practical with current technology. Previous implementations of MDI-QKD all use two symmetric channels with similar losses. However, the secret key rate is severely limited when different channels have different losses. Here we report the results of the first high-rate MDI-QKD experiment over $asymmetric$ channels. By using the recent 7-intensity optimization approach, we demonstrate $>$10x higher key rate than previous best-known protocols for MDI-QKD in the situation of large channel asymmetry, and extend the secure transmission distance by more than 20-50 km in standard telecom fiber. The results have moved MDI-QKD towards widespread applications in practical network settings, where the channel losses are asymmetric and user nodes could be dynamically added or deleted.
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