The out-of-time-order correlator (OTOC), recently analyzed in several physical contexts, is studied for low-dimensional chaotic systems through semiclassical expansions and numerical simulations. The semiclassical expansion for the OTOC yields a leading-order contribution in $hbar^2$ that is exponentially increasing with time within an intermediate, temperature-dependent, time-window. The growth-rate in such a regime is governed by the Lyapunov exponent of the underlying classical system and scales with the square-root of the temperature.