In this work we analyze quantum decoherence in neutrino oscillations considering the Open Quantum System framework and oscillations through matter for three neutrino families. Taking DUNE as a case study we performed sensitivity analyses for two neutrino flux configurations finding limits for the decoherence parameters. We also offer a physical interpretation for a new peak which arises at the $ u_{e}$ appearance probability with decoherence. The best sensitivity regions found for the decoherence parameters are $Gamma_{21}le 1.2times10^{-23},text{GeV}$ and $Gamma_{32}le 7.7times10^{-25},text{GeV}$ at $90%$ C. L.
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