Subscribe to the gold package and get unlimited access to Shamra Academy
Register a new userEstimating the division rate and kernel in the fragmentation equation
54
0
0.0
(
0
)
Authors
Marie Doumic
Ask ChatGPT about the research
No Arabic abstract
We consider the fragmentation equation $dfrac{partial}{partial t}f (t, x) = --B(x)f (t, x) + int_{ y=x}^{ y=infty} k(y, x)B(y)f (t, y)dy,$ and address the question of estimating the fragmentation parameters-i.e. the division rate $B(x)$ and the fragmentation kernel $k(y, x)$-from measurements of the size distribution $f (t, $times$)$ at various times. This is a natural question for any application where the sizes of the particles are measured experimentally whereas the fragmentation rates are unknown, see for instance (Xue, Radford, Biophys. Journal, 2013) for amyloid fibril breakage. Under the assumption of a polynomial division rate $B(x) = alpha x^{gamma}$ and a self-similar fragmentation kernel $k(y, x) = frac{1}{y} k_0 (x/ y)$, we use the asymptotic behaviour proved in (Escobedo, Mischler, Rodriguez-Ricard, Ann. IHP, 2004) to obtain uniqueness of the triplet $(alpha, gamma, k _0)$ and a representation formula for $k_0$. To invert this formula, one of the delicate points is to prove that the Mellin transform of the asymptotic profile never vanishes, what we do through the use of the Cauchy integral.
rate research
Read More
We are interested in the large time behavior of the solutions to the growth-fragmentation equation. We work in the space of integrable functions weighted with the principal dual eigenfunction of the growth-fragmentation operator. This space is the largest one in which we can expect convergence to the steady size distribution. Although this convergence is known to occur under fairly general conditions on the coefficients of the equation, we prove that it does not happen uniformly with respect to the initial data when the fragmentation rate in bounded. First we get the result for fragmentation kernels which do not form arbitrarily small fragments by taking advantage of the Dyson-Phillips series. Then we extend it to general kernels by using the notion of quasi-compactness and the fact that it is a topological invariant.
The objective is to prove the asynchronous exponential growth of the growth-fragmentation equation in large weighted $L^1$ spaces and under general assumptions on the coefficients. The key argument is the creation of moments for the solutions to the Cauchy problem, resulting from the unboundedness of the total fragmentation rate. It allows us to prove the quasi-compactness of the associated (rescaled) semigroup, which in turn provides the exponential convergence toward the projector on the Perron eigenfunction.
Is it possible to estimate the dependence of a growing and dividing population on a given trait in the case where this trait is not directly accessible by experimental measurements, but making use of measurements of another variable? This article adresses this general question for a very recent and popular model describing bacterial growth, the so-called incremental or adder model. In this model, the division rate depends on the increment of size between birth and division, whereas the most accessible trait is the size itself. We prove that estimating the division 10 rate from size measurements is possible, we state a reconstruction formula in a deterministic and then in a statistical setting, and solve numerically the problem on simulated and experimental data. Though this represents a severely ill-posed inverse problem, our numerical results prove to be satisfactory.
We consider the self-similar fragmentation equation with a superquadratic fragmentation rate and provide a quantitative estimate of the spectral gap.
Let $ngeq 3$, $alpha$, $betainmathbb{R}$, and let $v$ be a solution $Delta v+alpha e^v+beta xcdot abla e^v=0$ in $mathbb{R}^n$, which satisfies the conditions $lim_{Rtoinfty}frac{1}{log R}int_{1}^{R}rho^{1-n} (int_{B_{rho}}e^v,dx)drhoin (0,infty)$ and $|x|^2e^{v(x)}le A_1$ in $R^n$. We prove that $frac{v(x)}{log |x|}to -2$ as $|x|toinfty$ and $alpha>2beta$. As a consequence under a mild condition on $v$ we prove that the solution is radially symmetric about the origin.
Log in to be able to interact and post comments
comments
Fetching comments
Sign in to be able to follow your search criteria
