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The effect of a Durbin-Watson pretest on confidence intervals in regression

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 Added by Paul Kabaila
 Publication date 2018
and research's language is English




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Consider a linear regression model and suppose that our aim is to find a confidence interval for a specified linear combination of the regression parameters. In practice, it is common to perform a Durbin-Watson pretest of the null hypothesis of zero first-order autocorrelation of the random errors against the alternative hypothesis of positive first-order autocorrelation. If this null hypothesis is accepted then the confidence interval centred on the Ordinary Least Squares estimator is used; otherwise the confidence interval centred on the Feasible Generalized Least Squares estimator is used. We provide new tools for the computation, for any given design matrix and parameter of interest, of graphs of the coverage probability functions of the confidence interval resulting from this two-stage procedure and the confidence interval that is always centred on the Feasible Generalized Least Squares estimator. These graphs are used to choose the better confidence interval, prior to any examination of the observed response vector.



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We consider a linear regression model with regression parameter beta=(beta_1,...,beta_p) and independent and identically N(0,sigma^2) distributed errors. Suppose that the parameter of interest is theta = a^T beta where a is a specified vector. Define the parameter tau=c^T beta-t where the vector c and the number t are specified and a and c are linearly independent. Also suppose that we have uncertain prior information that tau = 0. We present a new frequentist 1-alpha confidence interval for theta that utilizes this prior information. We require this confidence interval to (a) have endpoints that are continuous functions of the data and (b) coincide with the standard 1-alpha confidence interval when the data strongly contradicts this prior information. This interval is optimal in the sense that it has minimum weighted average expected length where the largest weight is given to this expected length when tau=0. This minimization leads to an interval that has the following desirable properties. This interval has expected length that (a) is relatively small when the prior information about tau is correct and (b) has a maximum value that is not too large. The following problem will be used to illustrate the application of this new confidence interval. Consider a 2-by 2 factorial experiment with 20 replicates. Suppose that the parameter of interest theta is a specified simple effect and that we have uncertain prior information that the two-factor interaction is zero. Our aim is to find a frequentist 0.95 confidence interval for theta that utilizes this prior information.
We consider a general regression model, without a scale parameter. Our aim is to construct a confidence interval for a scalar parameter of interest $theta$ that utilizes the uncertain prior information that a distinct scalar parameter $tau$ takes the specified value $t$. This confidence interval should have good coverage properties. It should also have scaled expected length, where the scaling is with respect to the usual confidence interval, that (a) is substantially less than 1 when the prior information is correct, (b) has a maximum value that is not too large and (c) is close to 1 when the data and prior information are highly discordant. The asymptotic joint distribution of the maximum likelihood estimators $theta$ and $tau$ is similar to the joint distributions of these estimators in the particular case of a linear regression with normally distributed errors having known variance. This similarity is used to construct a confidence interval with the desired properties by using the confidence interval, computed using the R package ciuupi, that utilizes the uncertain prior information in this particular linear regression case. An important practical application of this confidence interval is to a quantal bioassay carried out to compare two similar compounds. In this context, the uncertain prior information is that the hypothesis of parallelism holds. We provide extensive numerical results that illustrate the properties of this confidence interval in this context.
136 - Christoph Dalitz 2018
Introductory texts on statistics typically only cover the classical two sigma confidence interval for the mean value and do not describe methods to obtain confidence intervals for other estimators. The present technical report fills this gap by first defining different methods for the construction of confidence intervals, and then by their application to a binomial proportion, the mean value, and to arbitrary estimators. Beside the frequentist approach, the likelihood ratio and the highest posterior density approach are explained. Two methods to estimate the variance of general maximum likelihood estimators are described (Hessian, Jackknife), and for arbitrary estimators the bootstrap is suggested. For three examples, the different methods are evaluated by means of Monte Carlo simulations with respect to their coverage probability and interval length. R code is given for all methods, and the practitioner obtains a guideline which method should be used in which cases.
Consider a linear regression model with n-dimensional response vector, regression parameter beta = (beta_1, ..., beta_p) and independent and identically N(0, sigma^2) distributed errors. Suppose that the parameter of interest is theta = a^T beta where a is a specified vector. Define the parameter tau = c^T beta - t where c and t are specified. Also suppose that we have uncertain prior information that tau = 0. Part of our evaluation of a frequentist confidence interval for theta is the ratio (expected length of this confidence interval)/(expected length of standard 1-alpha confidence interval), which we call the scaled expected length of this interval. We say that a 1-alpha confidence interval for theta utilizes this uncertain prior information if (a) the scaled expected length of this interval is significantly less than 1 when tau = 0, (b) the maximum value of the scaled expected length is not too much larger than 1 and (c) this confidence interval reverts to the standard 1-alpha confidence interval when the data happen to strongly contradict the prior information. Kabaila and Giri, 2009, JSPI present a new method for finding such a confidence interval. Let hatbeta denote the least squares estimator of beta. Also let hatTheta = a^T hatbeta and hattau = c^T hatbeta - t. Using computations and new theoretical results, we show that the performance of this confidence interval improves as |Corr(hatTheta, hattau)| increases and n-p decreases.
We derive a computationally convenient formula for the large sample coverage probability of a confidence interval for a scalar parameter of interest following a preliminary hypothesis test that a specified vector parameter takes a given value in a general regression model. Previously, this large sample coverage probability could only be estimated by simulation. Our formula only requires the evaluation, by numerical integration, of either a double or triple integral, irrespective of the dimension of this specified vector parameter. We illustrate the application of this formula to a confidence interval for the log odds ratio of myocardial infarction when the exposure is recent oral contraceptive use, following a preliminary test that two specified interactions in a logistic regression model are zero. For this real-life data, we compare this large sample coverage probability with the actual coverage probability of this confidence interval, obtained by simulation.
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