With the popularity of deep learning (DL), artificial intelligence (AI) has been applied in many areas of human life. Neural network or artificial neural network (NN), the main technique behind DL, has been extensively studied to facilitate computer vision and natural language recognition. However, the more we rely on information technology, the more vulnerable we are. That is, malicious NNs could bring huge threat in the so-called coming AI era. In this paper, for the first time in the literature, we propose a novel approach to design and insert powerful neural-level trojans or PoTrojan in pre-trained NN models. Most of the time, PoTrojans remain inactive, not affecting the normal functions of their host NN models. PoTrojans could only be triggered in very rare conditions. Once activated, however, the PoTrojans could cause the host NN models to malfunction, either falsely predicting or classifying, which is a significant threat to human society of the AI era. We would explain the principles of PoTrojans and the easiness of designing and inserting them in pre-trained deep learning models. PoTrojans doesnt modify the existing architecture or parameters of the pre-trained models, without re-training. Hence, the proposed method is very efficient.