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Register a new userIterative PET Image Reconstruction Using Convolutional Neural Network Representation
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PET image reconstruction is challenging due to the ill-poseness of the inverse problem and limited number of detected photons. Recently deep neural networks have been widely and successfully used in computer vision tasks and attracted growing interests in medical imaging. In this work, we trained a deep residual convolutional neural network to improve PET image quality by using the existing inter-patient information. An innovative feature of the proposed method is that we embed the neural network in the iterative reconstruction framework for image representation, rather than using it as a post-processing tool. We formulate the objective function as a constraint optimization problem and solve it using the alternating direction method of multipliers (ADMM) algorithm. Both simulation data and hybrid real data are used to evaluate the proposed method. Quantification results show that our proposed iterative neural network method can outperform the neural network denoising and conventional penalized maximum likelihood methods.
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Reconstruction of PET images is an ill-posed inverse problem and often requires iterative algorithms to achieve good image quality for reliable clinical use in practice, at huge computational costs. In this paper, we consider the PET reconstruction a dense prediction problem where the large scale contextual information is essential, and propose a novel architecture of multi-scale fully convolutional neural networks (msfCNN) for fast PET image reconstruction. The proposed msfCNN gains large receptive fields with both memory and computational efficiency, by using a downscaling-upscaling structure and dilated convolutions. Instead of pooling and deconvolution, we propose to use the periodic shuffling operation from sub-pixel convolution and its inverse to scale the size of feature maps without losing resolution. Residual connections were added to improve training. We trained the proposed msfCNN model with simulated data, and applied it to clinical PET data acquired on a Siemens mMR scanner. The results from real oncological and neurodegenerative cases show that the proposed msfCNN-based reconstruction outperforms the iterative approaches in terms of computational time while achieving comparable image quality for quantification. The proposed msfCNN model can be applied to other dense prediction tasks, and fast msfCNN-based PET reconstruction could facilitate the potential use of molecular imaging in interventional/surgical procedures, where cancer surgery can particularly benefit.
Single image dehazing, which aims to recover the clear image solely from an input hazy or foggy image, is a challenging ill-posed problem. Analysing existing approaches, the common key step is to estimate the haze density of each pixel. To this end, various approaches often heuristically designed haze-relevant features. Several recent works also automatically learn the features via directly exploiting Convolutional Neural Networks (CNN). However, it may be insufficient to fully capture the intrinsic attributes of hazy images. To obtain effective features for single image dehazing, this paper presents a novel Ranking Convolutional Neural Network (Ranking-CNN). In Ranking-CNN, a novel ranking layer is proposed to extend the structure of CNN so that the statistical and structural attributes of hazy images can be simultaneously captured. By training Ranking-CNN in a well-designed manner, powerful haze-relevant features can be automatically learned from massive hazy image patches. Based on these features, haze can be effectively removed by using a haze density prediction model trained through the random forest regression. Experimental results show that our approach outperforms several previous dehazing approaches on synthetic and real-world benchmark images. Comprehensive analyses are also conducted to interpret the proposed Ranking-CNN from both the theoretical and experimental aspects.
In this paper, we present a novel approach that uses deep learning techniques for colorizing grayscale images. By utilizing a pre-trained convolutional neural network, which is originally designed for image classification, we are able to separate content and style of different images and recombine them into a single image. We then propose a method that can add colors to a grayscale image by combining its content with style of a color image having semantic similarity with the grayscale one. As an application, to our knowledge the first of its kind, we use the proposed method to colorize images of ukiyo-e a genre of Japanese painting?and obtain interesting results, showing the potential of this method in the growing field of computer assisted art.
Our aim was to enhance visual quality and quantitative accuracy of dynamic positron emission tomography (PET)uptake images by improved image reconstruction, using sophisticated sparse penalty models that incorporate both 2D spatial+1D temporal (3DT) information. We developed two new 3DT PET reconstruction algorithms, incorporating different temporal and spatial penalties based on discrete cosine transform (DCT)w/ patches, and tensor nuclear norm (TNN) w/ patches, and compared to frame-by-frame methods; conventional 2D ordered subsets expectation maximization (OSEM) w/ post-filtering and 2D-DCT and 2D-TNN. A 3DT brain phantom with kinetic uptake (2-tissue model), and a moving 3DT cardiac/lung phantom was simulated and reconstructed. For the cardiac/lung phantom, an additional cardiac gated 2D-OSEM set was reconstructed. The structural similarity index (SSIM) and relative root mean squared error (rRMSE) relative ground truth was investigated. The image derived left ventricular (LV) volume for the cardiac/lung images was found by region growing and parametric images of the brain phantom were calculated. For the cardiac/lung phantom, 3DT-TNN yielded optimal images, and 3DT-DCT was best for the brain phantom. The optimal LV volume from the 3DT-TNN images was on average 11 and 55 percentage points closer to the true value compared to cardiac gated 2D-OSEM and 2D-OSEM respectively. Compared to 2D-OSEM, parametric images based on 3DT-DCT images generally had smaller bias and higher SSIM. Our novel methods that incorporate both 2D spatial and 1D temporal penalties produced dynamic PET images of higher quality than conventional 2D methods, w/o need for post-filtering. Breathing and cardiac motion were simultaneously captured w/o need for respiratory or cardiac gating. LV volumes were better recovered, and subsequently fitted parametric images were generally less biased and of higher quality.
Computed Tomography (CT) imaging technique is widely used in geological exploration, medical diagnosis and other fields. In practice, however, the resolution of CT image is usually limited by scanning devices and great expense. Super resolution (SR) methods based on deep learning have achieved surprising performance in two-dimensional (2D) images. Unfortunately, there are few effective SR algorithms for three-dimensional (3D) images. In this paper, we proposed a novel network named as three-dimensional super resolution convolutional neural network (3DSRCNN) to realize voxel super resolution for CT images. To solve the practical problems in training process such as slow convergence of network training, insufficient memory, etc., we utilized adjustable learning rate, residual-learning, gradient clipping, momentum stochastic gradient descent (SGD) strategies to optimize training procedure. In addition, we have explored the empirical guidelines to set appropriate number of layers of network and how to use residual learning strategy. Additionally, previous learning-based algorithms need to separately train for different scale factors for reconstruction, yet our single model can complete the multi-scale SR. At last, our method has better performance in terms of PSNR, SSIM and efficiency compared with conventional methods.
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