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Register a new userSequential 3D U-Nets for Biologically-Informed Brain Tumor Segmentation
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James Brown
Publication date
2017
fields
Informatics Engineering
and research's language is
English
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Deep learning has quickly become the weapon of choice for brain lesion segmentation. However, few existing algorithms pre-configure any biological context of their chosen segmentation tissues, and instead rely on the neural networks optimizer to develop such associations de novo. We present a novel method for applying deep neural networks to the problem of glioma tissue segmentation that takes into account the structured nature of gliomas - edematous tissue surrounding mutually-exclusive regions of enhancing and non-enhancing tumor. We trained multiple deep neural networks with a 3D U-Net architecture in a tree structure to create segmentations for edema, non-enhancing tumor, and enhancing tumor regions. Specifically, training was configured such that the whole tumor region including edema was predicted first, and its output segmentation was fed as input into separate models to predict enhancing and non-enhancing tumor. Our method was trained and evaluated on the publicly available BraTS dataset, achieving Dice scores of 0.882, 0.732, and 0.730 for whole tumor, enhancing tumor and tumor core respectively.
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We propose a novel, simple and effective method to integrate lesion prior and a 3D U-Net for improving brain tumor segmentation. First, we utilize the ground-truth brain tumor lesions from a group of patients to generate the heatmaps of different types of lesions. These heatmaps are used to create the volume-of-interest (VOI) map which contains prior information about brain tumor lesions. The VOI map is then integrated with the multimodal MR images and input to a 3D U-Net for segmentation. The proposed method is evaluated on a public benchmark dataset, and the experimental results show that the proposed feature fusion method achieves an improvement over the baseline methods. In addition, our proposed method also achieves a competitive performance compared to state-of-the-art methods.
Magnetic Resonance Imaging (MRI) is an important diagnostic tool for precise detection of various pathologies. Magnetic Resonance (MR) is more preferred than Computed Tomography (CT) due to the high resolution in MR images which help in better detection of neurological conditions. Graphical user interface (GUI) aided disease detection has become increasingly useful due to the increasing workload of doctors. In this proposed work, a novel two steps GUI technique for brain tumor segmentation as well as Brodmann area detec-tion of the segmented tumor is proposed. A data set of T2 weighted images of 15 patients is used for validating the proposed method. The patient data incor-porates variations in ethnicities, gender (male and female) and age (25-50), thus enhancing the authenticity of the proposed method. The tumors were segmented using Fuzzy C Means Clustering and Brodmann area detection was done using a known template, mapping each area to the segmented tumor image. The proposed method was found to be fairly accurate and robust in detecting tumor.
Segmentation of colorectal cancerous regions from 3D Magnetic Resonance (MR) images is a crucial procedure for radiotherapy which conventionally requires accurate delineation of tumour boundaries at an expense of labor, time and reproducibility. While deep learning based methods serve good baselines in 3D image segmentation tasks, small applicable patch size limits effective receptive field and degrades segmentation performance. In addition, Regions of interest (RoIs) localization from large whole volume 3D images serves as a preceding operation that brings about multiple benefits in terms of speed, target completeness, reduction of false positives. Distinct from sliding window or non-joint localization-segmentation based models, we propose a novel multitask framework referred to as 3D RoI-aware U-Net (3D RU-Net), for RoI localization and in-region segmentation where the two tasks share one backbone encoder network. With the region proposals from the encoder, we crop multi-level RoI in-region features from the encoder to form a GPU memory-efficient decoder for detailpreserving segmentation and therefore enlarged applicable volume size and effective receptive field. To effectively train the model, we designed a Dice formulated loss function for the global-to-local multi-task learning procedure. Based on the efficiency gains, we went on to ensemble models with different receptive fields to achieve even higher performance costing minor extra computational expensiveness. Extensive experiments were conducted on 64 cancerous cases with a four-fold cross-validation, and the results showed significant superiority in terms of accuracy and efficiency over conventional frameworks. In conclusion, the proposed method has a huge potential for extension to other 3D object segmentation tasks from medical images due to its inherent generalizability. The code for the proposed method is publicly available.
Gliomas appear with wide variation in their characteristics both in terms of their appearance and location on brain MR images, which makes robust tumour segmentation highly challenging, and leads to high inter-rater variability even in manual segmentations. In this work, we propose a triplanar ensemble network, with an independent tumour core prediction module, for accurate segmentation of these tumours and their sub-regions. On evaluating our method on the MICCAI Brain Tumor Segmentation (BraTS) challenge validation dataset, for tumour sub-regions, we achieved a Dice similarity coefficient of 0.77 for both enhancing tumour (ET) and tumour core (TC). In the case of the whole tumour (WT) region, we achieved a Dice value of 0.89, which is on par with the top-ranking methods from BraTS17-19. Our method achieved an evaluation score that was the equal 5th highest value (with our method ranking in 10th place) in the BraTS20 challenge, with mean Dice values of 0.81, 0.89 and 0.84 on ET, WT and TC regions respectively on the BraTS20 unseen test dataset.
The diagnosis and segmentation of tumors using any medical diagnostic tool can be challenging due to the varying nature of this pathology. Magnetic Reso- nance Imaging (MRI) is an established diagnostic tool for various diseases and disorders and plays a major role in clinical neuro-diagnosis. Supplementing this technique with automated classification and segmentation tools is gaining importance, to reduce errors and time needed to make a conclusive diagnosis. In this paper a simple three-step algorithm is proposed; (1) identification of patients that present with tumors, (2) automatic selection of abnormal slices of the patients, and (3) segmentation and detection of the tumor. Features were extracted by using discrete wavelet transform on the normalized images and classified by support vector machine (for step (1)) and random forest (for step (2)). The 400 subjects were divided in a 3:1 ratio between training and test with no overlap. This study is novel in terms of use of data, as it employed the entire T2 weighted slices as a single image for classification and a unique combination of contralateral approach with patch thresholding for segmentation, which does not require a training set or a template as is used by most segmentation studies. Using the proposed method, the tumors were segmented accurately with a classification accuracy of 95% with 100% specificity and 90% sensitivity.
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