While rich clusters are powerful sources of X-rays, gamma-ray emission from these large cosmic structures has not been detected yet. X-ray radiative energy losses in the central regions of relaxed galaxy clusters are so strong that one needs to consider special sources of energy, likely AGN feedback, to suppress catastrophic cooling of the gas. We consider a model of AGN feedback that postulates that the AGN supplies the energy to the gas by inflating bubbles of relativistic plasma, whose energy content is dominated by cosmic-ray (CR) hadrons. If most of these hadrons can quickly escape the bubbles, then collisions of CRs with thermal protons in the intracluster medium (ICM) should lead to strong gamma-ray emission, unless fast diffusion of CRs removes them from the cluster. Therefore, the lack of detections with modern gamma-ray telescopes sets limits on the confinement time of CR hadrons in bubbles and CR diffusive propagation in the ICM.
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