The quantum phases of 2-leg spin-1/2 ladders with skewed rungs are obtained using exact diagonalization of systems with up to 26 spins and by density matrix renormalization group calculations to 500 spins. The ladders have isotropic antiferromagnetic (AF) exchange $J_2 > 0$ between first neighbors in the legs, variable isotropic AF exchange $J_1$ between some first neighbors in different legs, and an unpaired spin per odd-membered ring when $J_1 gg J_2$. Ladders with skewed rungs and variable $J_1$ have frustrated AF interactions leading to multiple quantum phases: AF at small $J_1$, either F or AF at large $J_1$, as well as bond-order-wave phases or reentrant AF (singlet) phases at intermediate $J_1$.
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