During the last several years remarkable progress has been made in numerical calculations of dimensionally regulated multi-loop Feynman diagrams using Mellin-Barnes (MB) representations. The bottlenecks were non-planar diagrams and Minkowskian kinematics. The method has been proved to work in highly non-trivial physical application (two-loop electroweak bosonic corrections to the $Z to b bar{{b}}$ decay), and cross-checked with the sector decomposition (SD) approach. In fact, both approaches have their pros and cons. In calculation of multidimensional integrals, depending on masses and scales involved, they are complementary. A powerful top-bottom approach to the numerical integration of multidimensional MB integrals is automatized in the MB-suite AMBRE/MB/ MBtools/MBnumerics/CUBA. Key elements are a dedicated use of the Cheng-Wu theorem for non-planar topologies and of shifts and deformations of the integration contours. An alternative bottom-up approach starting with complex 1-dimensional MB-integrals, based on the exploration of steepest descent integration contours in Minkowskian kinematics, is also discussed. Short and long term prospects of the MB-method for multi-loop applications to LHC- and LC-physics are discussed.
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