In the present study, a general probabilistic design framework is developed for cyclic fatigue life prediction of metallic hardware using methods that address uncertainty in experimental data and computational model. The methodology involves (i) fatigue test data conducted on coupons of Ti6Al4V material (ii) continuum damage mechanics based material constitutive models to simulate cyclic fatigue behavior of material (iii) variance-based global sensitivity analysis (iv) Bayesian framework for model calibration and uncertainty quantification and (v) computational life prediction and probabilistic design decision making under uncertainty. The outcomes of computational analyses using the experimental data prove the feasibility of the probabilistic design methods for model calibration in presence of incomplete and noisy data. Moreover, using probabilistic design methods result in assessment of reliability of fatigue life predicted by computational models.