Because of their universal nature, Fano fluctuations are expected to influence the response of superconducting nanowire single-photon detectors (SNSPDs). We predict that photon counting rate ($PCR$) as a function of bias current ($I_B$) in SNSPDs is described by an integral over a transverse coordinate-dependent complementary error function. The latter describes smearing of local responses due to Fano fluctuations of the amount of energy deposited into electronic system. The finite width, $sigma$, of the $PCR$ vs $I_B$ arises from fluctuations in the energy partition between quasiparticles and phonons during the energy down-conversion cascade. In narrow-nanowire SNSPDs the local responses are uniform, and the effect of Fano-fluctuations on $sigma$ is dominant. In wide-nanowire SNSPDs with strong coordinate dependence of local responses due to vortex-antivortex unbinding and vortex entry from edges, Fano-fluctuations smear singularities imprinted by vorticity on the transition part of $PCR$ curve. We demonstrate good agreement between theory and experiments for a series of bath temperatures and photon energies in narrow-wire WSi SNSPDs. The time-resolved hotspot relaxation curves predicted by Fano fluctuations match the Lorentzian shapes observed in experiments over the whole range of bias currents investigated except for their tails.
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