We study the arithmetically Cohen-Macaulay (ACM) property for finite sets of points in multiprojective spaces, especially $(mathbb P^1)^n$. A combinatorial characterization, the $(star)$-property, is known in $mathbb P^1 times mathbb P^1$. We propose a combinatorial property, $(star_n)$, that directly generalizes the $(star)$-property to $(mathbb P^1)^n$ for larger $n$. We show that $X$ is ACM if and only if it satisfies the $(star_n)$-property. The main tool for several of our results is an extension to the multiprojective setting of certain liaison methods in projective space.