Based on $e^+e^-$ annihilation data samples collected with the BESIII detector at the BEPCII collider at 13 center of mass energies from 4.008 to 4.600 GeV, measurements of the Born cross section of $e^{+}e^{-}rightarrow p bar{p} pi^{0}$ are performed. No significant resonant structure is observed in the measured energy-dependent cross section. The upper limit on the Born cross section of $e^{+}e^{-}rightarrow Y(4260) rightarrow p bar{p} pi^{0}$ at the 90% C.L. is determined to be 0.01 pb.