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Register a new userExplaining Radiological Emphysema Subtypes with Unsupervised Texture Prototypes: MESA COPD Study
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Added by
Jie Yang
Publication date
2016
fields
Informatics Engineering
and research's language is
English
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Pulmonary emphysema is traditionally subcategorized into three subtypes, which have distinct radiological appearances on computed tomography (CT) and can help with the diagnosis of chronic obstructive pulmonary disease (COPD). Automated texture-based quantification of emphysema subtypes has been successfully implemented via supervised learning of these three emphysema subtypes. In this work, we demonstrate that unsupervised learning on a large heterogeneous database of CT scans can generate texture prototypes that are visually homogeneous and distinct, reproducible across subjects, and capable of predicting accurately the three standard radiological subtypes. These texture prototypes enable automated labeling of lung volumes, and open the way to new interpretations of lung CT scans with finer subtyping of emphysema.
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Pulmonary emphysema overlaps considerably with chronic obstructive pulmonary disease (COPD), and is traditionally subcategorized into three subtypes previously identified on autopsy. Unsupervised learning of emphysema subtypes on computed tomography (CT) opens the way to new definitions of emphysema subtypes and eliminates the need of thorough manual labeling. However, CT-based emphysema subtypes have been limited to texture-based patterns without considering spatial location. In this work, we introduce a standardized spatial mapping of the lung for quantitative study of lung texture location, and propose a novel framework for combining spatial and texture information to discover spatially-informed lung texture patterns (sLTPs) that represent novel emphysema subtypes. Exploiting two cohorts of full-lung CT scans from the MESA COPD and EMCAP studies, we first show that our spatial mapping enables population-wide study of emphysema spatial location. We then evaluate the characteristics of the sLTPs discovered on MESA COPD, and show that they are reproducible, able to encode standard emphysema subtypes, and associated with physiological symptoms.
Features that capture well the textural patterns of a certain class of images are crucial for the performance of texture segmentation methods. The manual selection of features or designing new ones can be a tedious task. Therefore, it is desirable to automatically adapt the features to a certain image or class of images. Typically, this requires a large set of training images with similar textures and ground truth segmentation. In this work, we propose a framework to learn features for texture segmentation when no such training data is available. The cost function for our learning process is constructed to match a commonly used segmentation model, the piecewise constant Mumford-Shah model. This means that the features are learned such that they provide an approximately piecewise constant feature image with a small jump set. Based on this idea, we develop a two-stage algorithm which first learns suitable convolutional features and then performs a segmentation. We note that the features can be learned from a small set of images, from a single image, or even from image patches. The proposed method achieves a competitive rank in the Prague texture segmentation benchmark, and it is effective for segmenting histological images.
Dynamic Time Warping (DTW) is widely used for temporal data processing. However, existing methods can neither learn the discriminative prototypes of different classes nor exploit such prototypes for further analysis. We propose Discriminative Prototype DTW (DP-DTW), a novel method to learn class-specific discriminative prototypes for temporal recognition tasks. DP-DTW shows superior performance compared to conventional DTWs on time series classification benchmarks. Combined with end-to-end deep learning, DP-DTW can handle challenging weakly supervised action segmentation problems and achieves state of the art results on standard benchmarks. Moreover, detailed reasoning on the input video is enabled by the learned action prototypes. Specifically, an action-based video summarization can be obtained by aligning the input sequence with action prototypes.
Given the outstanding progress that convolutional neural networks (CNNs) have made on natural image classification and object recognition problems, it is shown that deep learning methods can achieve very good recognition performance on many texture datasets. However, while CNNs for natural image classification/object recognition tasks have been revealed to be highly vulnerable to various types of adversarial attack methods, the robustness of deep learning methods for texture recognition is yet to be examined. In our paper, we show that there exist small image-agnostic/univesal perturbations that can fool the deep learning models with more than 80% of testing fooling rates on all tested texture datasets. The computed perturbations using various attack methods on the tested datasets are generally quasi-imperceptible, containing structured patterns with low, middle and high frequency components.
The aim of few-shot learning (FSL) is to learn how to recognize image categories from a small number of training examples. A central challenge is that the available training examples are normally insufficient to determine which visual features are most characteristic of the considered categories. To address this challenge, we organize these visual features into facets, which intuitively group features of the same kind (e.g. features that are relevant to shape, color, or texture). This is motivated from the assumption that (i) the importance of each facet differs from category to category and (ii) it is possible to predict facet importance from a pre-trained embedding of the category names. In particular, we propose an adaptive similarity measure, relying on predicted facet importance weights for a given set of categories. This measure can be used in combination with a wide array of existing metric-based methods. Experiments on miniImageNet and CUB show that our approach improves the state-of-the-art in metric-based FSL.
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