Here we present the latest results of the charged Lepton Flavor Violation process searches at the BESIII experiment in the decay of $J/psi$ to $emu$, using $(225.3pm2.8)times10^6$ $J/psi$ events collected with the BESIII detector at the BEPCII collider. An upper limit on the branching fraction of $B(J/psi rightarrow emu)<1.6times10^{-7}$ (90$%$ C.L.) is obtained. The prospects and challenges with the future data are also discussed based on MC simulation.