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Conventional microscope objective lenses are diffraction limited, which means that they cannot resolve features smaller than half the illumination wavelength. Under white light illumination, such resolution limit is about 250-300 nm for an ordinary microscope. In this paper, we demonstrate a new superlensing objective lens which has a resolution of about 100 nm, offering at least two times resolution improvement over conventional objectives in resolution. This is achieved by integrating a conventional microscope objective lens with a superlensing microsphere lens using a 3D printed lens adaptor. The new objective lens was used for label-free super-resolution imaging of 100 nm-sized engineering and biological samples, including a Blu-ray disc sample, semiconductor chip and adenoviruses. Our work creates a solid base for developing a commercially-viable superlens prototype, which has potential to transform the field of optical microscopy and imaging.
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Imaging and manipulating individual atoms with submicrometer separation can be instrumental for quantum simulation of condensed matter Hamiltonians and quantum computation with neutral atoms. Quantum gas microscope experiments in most cases rely on quite costly solutions. Here we present an open-source design of a microscope objective for atomic strontium consisting solely of off-the-shelf lenses that is diffraction-limited for 461${,}$nm light. A prototype built with a simple stacking design is measured to have a resolution of 0.63(4)${,mu}$m, which is in agreement with the predicted value. This performance, together with the near diffraction-limited performance for 532${,}$nm light makes this design useful for both quantum gas microscopes and optical tweezer experiments with strontium. Our microscope can easily be adapted to experiments with other atomic species such as erbium, ytterbium, and dysprosium, as well as Rydberg experiments with rubidium.
We present a comparison between lens cavity filters and atomic line filters, discussing their relative merits for applications in quantum optics. We describe the design, characterization and stabilization procedure of a lens cavity filter, which consists of a high-reflection coated commercially available plano-convex lens, and compare it to an ultra-narrow atomic band-pass filter utilizing the D$_{2}$ absorption line in atomic rubidium vapor. We find that the cavity filter peak transmission frequency and bandwidth can be chosen arbitrarily but the transmission frequency is subject to thermal drift and the cavity needs stabilization to better than a few mK, while the atomic filter is intrinsically stable and tied to an atomic resonance frequency such that it can be used in a non-laboratory environment.
Although fluorescence is the prevailing labeling technique in biosensing applications, sensitivity improvement is still a striving challenge. We show that coating standard microscope slides with nanoroughened silver films provides a high fluorescence signal enhancement due to plasmonic interactions. As a proof of concept, we applied these films with tailored plasmonic properties to DNA microarrays. Using common optical scanning devices, we achieved signal amplifications by more than 40-fold.
Dedicated accelerometers have been developed for the MICROSCOPE mission taking into account the specific range of acceleration to be measured on board the satellite. Considering one micro-g and even less as the full range of the instrument, leads to a customized concept and a high performance electronics for the sensing and servo-actuations of the accelerometer test-masses. In addition to a very accurate geometrical sensor core, a high performance electronics architecture provides the measurement of the weak electrostatic forces and torques applied to the test-masses. A set of capacitive sensors delivers the position and the attitude of the test-mass with respect to a very steady gold coated cage made in silica. The voltages applied on the electrodes surrounding each test-mass are finely controlled to generate the adequate electrical field and so the electrostatic pressures on the test-mass. This field maintains the test-mass motionless with respect to the instrument structure. Digital control laws are implemented in order to enable instrument operation flexibility and a weak position sensor noise. These electronics provide both the scientific data for MICROSCOPEs test of General Relativity and the data for the satellite drag-free and attitude control system (DFACS).
The OpenFlexure Microscope is a 3D printed, low-cost microscope capable of automated image acquisition through the use of a motorised translation stage and a Raspberry Pi imaging system. This automation has applications in research and healthcare, including in supporting the diagnosis of malaria in low resource settings. The plasmodium parasites which cause malaria require high magnification imaging, which has a shallow depth of field, necessitating the development of an accurate and precise autofocus procedure. We present methods of identifying the focal plane of the microscope, and procedures for reliably acquiring a stack of focused images on a system affected by backlash and drift. We also present and assess a method to verify the success of autofocus during the scan. The speed, reliability and precision of each method is evaluated, and the limitations discussed in terms of the end users requirements.
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