Let $R^{n+1, n}$ be the vector space $R^{2n+1}$ equipped with the bilinear form $(X,Y)=X^t C_n Y$ of index $n$, where $C_n= sum_{i=1}^{2n+1} (-1)^{n+i-1} e_{i, 2n+2-i}$. A smooth $gamma: Rto R^{n+1,n}$ is {it isotropic} if $gamma, gamma_x, ldots, gamma_x^{(2n)}$ are linearly independent and the span of $gamma, ldots, gamma_x^{(n-1)}$ is isotropic. Given an isotropic curve, we show that there is a unique up to translation parameter such that $(gamma_x^{(n)}, gamma_x^{(n)})=1$ (we call such parameter the isotropic parameter) and there also exists a natural moving frame. In this paper, we consider two sequences of curve flows on the space of isotropic curves parametrized by isotropic parameter. We show that differential invariants of these isotropic curves satisfy Drinfeld-Sokolovs KdV type soliton hierarchies associated to the affine Kac-Moody algebra $hat B_n^{(1)}$ and $hat A_{2n}^{(2)}$ Then we use techniques from soliton theory to construct bi-Hamiltonian structure, conservation laws, Backlund transformations and permutability formulas for these curve flows.