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Register a new userThermal x-ray diffraction and near-field phase contrast imaging
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Using higher-order coherence of thermal light sources, the resolution power of standard x-ray imaging techniques can be enhanced. In this work, we applied the higher-order measurement to far-field x-ray diffraction and near-field phase contrast imaging (PCI), in order to achieve superresolution in x-ray diffraction and obtain enhanced intensity contrast in PCI. The cost of implementing such schemes is minimal compared to the methods that achieve similar effects by using entangled x-ray photon pairs.
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Like many other advanced imaging methods, x-ray phase contrast imaging and tomography require mathematical inversion of the observed data to obtain real-space information. While an accurate forward model describing the generally nonlinear image formation from a given object to the observations is often available, explicit inversion formulas are typically not known. Moreover, the measured data might be insufficient for stable image reconstruction, in which case it has to be complemented by suitable a priori information. In this work, regularized Newton methods are presented as a general framework for the solution of such ill-posed nonlinear imaging problems. For a proof of principle, the approach is applied to x-ray phase contrast imaging in the near-field propagation regime. Simultaneous recovery of the phase- and amplitude from a single near-field diffraction pattern without homogeneity constraints is demonstrated for the first time. The presented methods further permit all-at-once phase contrast tomography, i.e. simultaneous phase retrieval and tomographic inversion. We demonstrate the potential of this approach by three-dimensional imaging of a colloidal crystal at 95 nm isotropic resolution.
The Fourier inversion of phased coherent diffraction patterns offers images without the resolution and depth-of-focus limitations of lens-based tomographic systems. We report on our recent experimental images inverted using recent developments in phase retrieval algorithms, and summarize efforts that led to these accomplishments. These include ab-initio reconstruction of a two-dimensional test pattern, infinite depth of focus image of a thick object, and its high-resolution (~10 nm resolution) three-dimensional image. Developments on the structural imaging of low density aerogel samples are discussed.
We report the initial demonstrations of the use of single crystals in indirect x-ray imaging for x-ray phase contrast imaging at the Washington University in St. Louis Computational Bioimaging Laboratory (CBL). Based on single Gaussian peak fits to the x-ray images, we observed a four times smaller system point spread function (21 {mu}m (FWHM)) with the 25-mm diameter single crystals than the reference polycrystalline phosphors 80-{mu}m value. Potential fiber-optic plate depth-of-focus aspects and 33-{mu}m diameter carbon fiber imaging are also addressed.
X-ray Talbot-Lau interferometer has been used widely to conduct phase contrast imaging with a conventional low-brilliance x-ray source. Typically, in this technique, background correction has to be performed in order to obtain the pure signal of the sample under inspection. In this study, we reported on a research on the background correction strategies within this technique, especially we introduced a new phase unwrapping solution for one conventional background correction method, the key point of this new solution is changing the initial phase of each pixel by a cyclic shift operation on the raw images collected in phase stepping scan. Experimental result and numerical analysis showed that the new phase unwrapping algorithm could successfully subtract contribution of the systems background without error. Moreover, a potential advantage of this phase unwrapping strategy is that its effective phase measuring range could be tuned flexibly in some degree for example to be (-pi+3, pi+3], thus it would find usage in certain case because measuring range of the currently widely used background correction method is fixed to be (-pi, pi].
Since their discovery in 1896, x-rays have had a profound impact on science, medicine and technology. Here we show that the x-rays from a novel tabletop source of bright coherent synchrotron radiation can be applied to phase contrast imaging of biological specimens, yielding superior image quality and avoiding the need for scarce or expensive conventional sources.
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