When laser intensity exceeds 10^22W/cm^2, photons with energy above MeV can be generated from high-order harmonics process in the laser-plasma interaction. We find that under such laser intensity, QED effect plays a dominating role in the radiation pattern. Contrast to the gas and relativistic HHG processes, both the occurrence and energy of gamma-ray emission produced by QED harmonics are random and QED harmonics are usually not coherent, while the property of high intensity and ultra-short duration is conserved. Our simulation shows that the period of gamma-ray train is half of the laser period and the peak intensity is 1.4e22W/cm^2. This new harmonic production with QED effects are crucial to light-matter interaction in strong field and can be verified in experiments by 10PW laser facilities in the near future.
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