In this paper, we investigate the cross-media retrieval between images and text, i.e., using image to search text (I2T) and using text to search images (T2I). Existing cross-media retrieval methods usually learn one couple of projections, by which the original features of images and text can be projected into a common latent space to measure the content similarity. However, using the same projections for the two different retrieval tasks (I2T and T2I) may lead to a tradeoff between their respective performances, rather than their best performances. Different from previous works, we propose a modality-dependent cross-media retrieval (MDCR) model, where two couples of projections are learned for different cross-media retrieval tasks instead of one couple of projections. Specifically, by jointly optimizing the correlation between images and text and the linear regression from one modal space (image or text) to the semantic space, two couples of mappings are learned to project images and text from their original feature spaces into two common latent subspaces (one for I2T and the other for T2I). Extensive experiments show the superiority of the proposed MDCR compared with other methods. In particular, based the 4,096 dimensional convolutional neural network (CNN) visual feature and 100 dimensional LDA textual feature, the mAP of the proposed method achieves 41.5%, which is a new state-of-the-art performance on the Wikipedia dataset.