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We formulate the large deviations for a class of two scale chemical kinetic processes motivated from biological applications. The result is successfully applied to treat a genetic switching model with positive feedbacks. The corresponding Hamiltonian is convex with respect to the momentum variable as a by-product of the large deviation theory. This property ensures its superiority in the rare event simulations compared with the result obtained by formal WKB asymptotics. The result is of general interest to understand the large deviations for multiscale problems.
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Let $X^{(delta)}$ be a Wishart process of dimension $delta$, with values in the set of positive matrices of size $m$. We are interested in the large deviations for a family of matrix-valued processes ${delta^{-1} X_t^{(delta)}, t leq 1 }$ as $delta$ tends to infinity. The process $X^{(delta)}$ is a solution of a stochastic differential equation with a degenerate diffusion coefficient. Our approach is based upon the introduction of exponential martingales. We give some applications to large deviations for functionals of the Wishart processes, for example the set of eigenvalues.
Motivated by the study of rare events for a typical genetic switching model in systems biology, in this paper we aim to establish the general two-scale large deviations for chemical reaction systems. We build a formal approach to explicitly obtain the large deviation rate functionals for the considered two-scale processes based upon the second-quantization path integral technique. We get three important types of large deviation results when the underlying two times scales are in three different regimes. This is realized by singular perturbation analysis to the rate functionals obtained by path integral. We find that the three regimes possess the same deterministic mean-field limit but completely different chemical Langevin approximations. The obtained results are natural extensions of the classical large volume limit for chemical reactions. We also discuss its implication on the single-molecule Michaelis-Menten kinetics. Our framework and results can be applied to understand general multi-scale systems including diffusion processes.
We study two one-parameter families of point processes connected to random matrices: the Sine_beta and Sch_tau processes. The first one is the bulk point process limit for the Gaussian beta-ensemble. For beta=1, 2 and 4 it gives the limit of the GOE, GUE and GSE models of random matrix theory. In particular, for beta=2 it is a determinantal point process conjectured to have similar behavior to the critical zeros of the Riemann zeta-function. The second process can be obtained as the bulk scaling limit of the spectrum of certain discrete one-dimensional random Schrodinger operators. Both processes have asymptotically constant average density, in our normalization one expects close to lambda/(2pi) points in a large interval of length lambda. Our main results are large deviation principles for the average densities of the processes, essentially we compute the asymptotic probability of seeing an unusual average density in a large interval. Our approach is based on the representation of the counting functions of these processes using stochastic differential equations. We also prove path level large deviation principles for the arising diffusions. Our techniques work for the full range of parameter values. The results are novel even in the classical beta=1, 2 and 4 cases for the Sine_beta process. They are consistent with the existing rigorous results on large gap probabilities and confirm the physical predictions made using log-gas arguments.
We formulate large deviations principle (LDP) for diffusion pair $(X^epsilon,xi^epsilon)=(X_t^epsilon,xi_t^epsilon)$, where first component has a small diffusion parameter while the second is ergodic Markovian process with fast time. More exactly, the LDP is established for $(X^epsilon, u^epsilon)$ with $ u^epsilon(dt,dz)$ being an occupation type measure corresponding to $xi_t^epsilon$. In some sense we obtain a combination of Freidlin-Wentzells and Donsker-Varadhans results. Our approach relies the concept of the exponential tightness and Puhalskiis theorem.
In this paper we study several aspects of the growth of a supercritical Galton-Watson process {Z_n:nge1}, and bring out some criticality phenomena determined by the Schroder constant. We develop the local limit theory of Z_n, that is, the behavior of P(Z_n=v_n) as v_n earrow infty, and use this to study conditional large deviations of {Y_{Z_n}:nge1}, where Y_n satisfies an LDP, particularly of {Z_n^{-1}Z_{n+1}:nge1} conditioned on Z_nge v_n.
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