Let k>2. We prove that the cotangent bundles of oriented homotopy (2k-1)-spheres S and S are symplectomorphic only if the classes defined by S and S agree up to sign in the quotient group of oriented homotopy spheres modulo those which bound parallelizable manifolds. We also show that if the connect sum of real projective space of dimension (4k-1) and a homotopy (4k-1)-sphere admits a Lagrangian embedding in complex projective space, then twice the homotopy sphere framed bounds. The proofs build on previous work of Abouzaid and the authors, in combination with a new cut-and-paste argument, which also gives rise to some interesting explicit exact Lagrangian embeddings into plumbings. As another application, we show that there are re-parameterizations of the zero-section in the cotangent bundle of a sphere which are not Hamiltonian isotopic (as maps, rather than as submanifolds) to the original zero-section.
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