We identify a class of quasi-compact semi-separated (qcss) twisted presheaves of algebras A for which well-behaved Grothendieck abelian categories of quasi-coherent modules Qch(A) are defined. This class is stable under algebraic deformation, giving rise to a 1-1 correspondence between algebraic deformations of A and abelian deformations of Qch(A). For a qcss presheaf A, we use the Gerstenhaber-Schack (GS) complex to explicitely parameterize the first order deformations. For a twisted presheaf A with central twists, we descibe an alternative category QPr(A) of quasi-coherent presheaves which is equivalent to Qch(A), leading to an alternative, equivalent association of abelian deformations to GS cocycles of qcss presheaves of commutative algebras. Our construction applies to the restriction O of the structure sheaf of a scheme X to a finite semi-separating open affine cover (for which we have an equivalence between Qch(O) and Qch(X)). Under a natural identification of Gerstenhaber-Schack cohomology of O and Hochschild cohomology of X, our construction is shown to be equivalent to Todas construction in the smooth case.
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