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Design and Analysis of Wireless Communication Systems Using Diffusion-Based Molecular Communication Among Bacteria

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 Added by Arash Einolghozati
 Publication date 2014
and research's language is English




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The design of biologically-inspired wireless communication systems using bacteria as the basic element of the system is initially motivated by a phenomenon called emph{Quorum Sensing}. Due to high randomness in the individual behavior of a bacterium, reliable communication between two bacteria is almost impossible. Therefore, we have recently proposed that a population of bacteria in a cluster is considered as a bio node in the network capable of molecular transmission and reception. This proposition enables us to form a reliable bio node out of many unreliable bacteria. In this paper, we study the communication between two nodes in such a network where information is encoded in the concentration of molecules by the transmitter. The molecules produced by the bacteria in the transmitter node propagate through the diffusion channel. Then, the concentration of molecules is sensed by the bacteria population in the receiver node which would decode the information and output light or fluorescent as a result. The uncertainty in the communication is caused by all three components of communication, i.e., transmission, propagation and reception. We study the theoretical limits of the information transfer rate in the presence of such uncertainties. Finally, we consider M-ary signaling schemes and study their achievable rates and corresponding error probabilities.



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Molecular communication is an expanding body of research. Recent advances in biology have encouraged using genetically engineered bacteria as the main component in the molecular communication. This has stimulated a new line of research that attempts to study molecular communication among bacteria from an information-theoretic point of view. Due to high randomness in the individual behavior of the bacterium, reliable communication between two bacteria is almost impossible. Therefore, we recently proposed that a population of bacteria in a cluster is considered as a node capable of molecular transmission and reception. This proposition enables us to form a reliable node out of many unreliable bacteria. The bacteria inside a node sense the environment and respond accordingly. In this paper, we study the communication between two nodes, one acting as the transmitter and the other as the receiver. We consider the case in which the information is encoded in the concentration of molecules by the transmitter. The molecules produced by the bacteria in the transmitter node propagate in the environment via the diffusion process. Then, their concentration sensed by the bacteria in the receiver node would decode the information. The randomness in the communication is caused by both the error in the molecular production at the transmitter and the reception of molecules at the receiver. We study the theoretical limits of the information transfer rate in such a setup versus the number of bacteria per node. Finally, we consider M-ary modulation schemes and study the achievable rates and their error probabilities.
Molecular communication between biological entities is a new paradigm in communications. Recently, we studied molecular communication between two nodes formed from synthetic bacteria. Due to high randomness in behavior of bacteria, we used a population of them in each node. The reliability of such communication systems depends on both the maximum concentration of molecules that a transmitter node is able to produce at the receiver node as well as the number of bacteria in each nodes. This maximum concentration of molecules falls with distance which makes the communication to the far nodes nearly impossible. In order to alleviate this problem, in this paper, we propose to use a molecular relaying node. The relay node can resend the message either by the different or the same type of molecules as the original signal from the transmitter. We study two scenarios of relaying. In the first scenario, the relay node simply senses the received concentration and forwards it to the receiver. We show that this sense and forward scenario, depending on the type of molecules used for relaying, results in either increasing the range of concentration of molecules at the receiver or increasing the effective number of bacteria in the receiver node. For both cases of sense and forward relaying, we obtain the resulting improvement in channel capacity. We conclude that multi-type molecular relaying outperforms the single-type relaying. In the second scenario, we study the decode and forward relaying for the M-ary signaling scheme. We show that this relaying strategy increases the reliability of M-ary communication significantly.
There are now several works on the use of the additive inverse Gaussian noise (AIGN) model for the random transit time in molecular communication~(MC) channels. The randomness invariably causes inter-symbol interference (ISI) in MC, an issue largely ignored or simplified. In this paper we derive an upper bound and two lower bounds for MC based on amplitude shift keying (ASK) in presence of ISI. The Blahut-Arimoto algorithm~(BAA) is modified to find the input distribution of transmitted symbols to maximize the lower bounds. Our results show that over wide parameter values the bounds are close.
A diffusion-based molecular communication system has two major components: the diffusion in the medium, and the ligand-reception. Information bits, encoded in the time variations of the concentration of molecules, are conveyed to the receiver front through the molecular diffusion in the medium. The receiver, in turn, measures the concentration of the molecules in its vicinity in order to retrieve the information. This is done via ligand-reception process. In this paper, we develop models to study the constraints imposed by the concentration sensing at the receiver side and derive the maximum rate by which a ligand-receiver can receive information. Therefore, the overall capacity of the diffusion channel with the ligand receptors can be obtained by combining the results presented in this paper with our previous work on the achievable information rate of molecular communication over the diffusion channel.
The prospect of new biological and industrial applications that require communication in micro-scale, encourages research on the design of bio-compatible communication networks using networking primitives already available in nature. One of the most promising candidates for constructing such networks is to adapt and engineer specific types of bacteria that are capable of sensing, actuation, and above all, communication with each other. In this paper, we describe a new architecture for networks of bacteria to form a data collecting network, as in traditional sensor networks. The key to this architecture is the fact that the node in the network itself is a bacterial colony; as an individual bacterium (biological agent) is a tiny unreliable element with limited capabilities. We describe such a network under two different scenarios. We study the data gathering (sensing and multihop communication) scenario as in sensor networks followed by the consensus problem in a multi-node network. We will explain as to how the bacteria in the colony collectively orchestrate their actions as a node to perform sensing and relaying tasks that would not be possible (at least reliably) by an individual bacterium. Each single bacterium in the colony forms a belief by sensing external parameter (e.g., a molecular signal from another node) from the medium and shares its belief with other bacteria in the colony. Then, after some interactions, all the bacteria in the colony form a common belief and act as a single node. We will model the reception process of each individual bacteria and will study its impact on the overall functionality of a node. We will present results on the reliability of the multihop communication for data gathering scenario as well as the speed of convergence in the consensus scenario.
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