Transition-metal oxides offer an opportunity to explore unconventional superconductors, where the superconductivity (SC) is often interrelated with novel phenomena such as spin/charge order, fluctuations, and Fermi surface instability (1-3). LiTi2O4 (LTO) is a unique compound in that it is the only known spinel oxide superconductor. In addition to electron-phonon coupling, electron-electron and spin fluctuation contributions have been suggested as playing important roles in the microscopic mechanism for its superconductivity (4-8). However, the lack of high quality single crystals has thus far prevented systematic investigation of their transport properties (9). Here, we report a careful study of transport and tunneling spectroscopy in epitaxial LTO thin films. In the superconducting state, the energy gap was found to decrease as a quadratic function of magnetic field. In the normal state, an unusual magnetoresistance (MR) was observed where it changes from anisotropic positive to isotropic negative as the temperature is increased. A constant charge carrier concentration without any abrupt change in lattice parameters as a function of temperature suggests that the isotropic MR stems from the suppression of spin scattering/fluctuations, while the anisotropic term originates from an orbital contribution. These observations point to an important role strong correlations play in this unique superconductor.