The development of hybrid quantum systems is central to the advancement of emerging quantum technologies, including quantum information science and quantum-assisted sensing. The recent demonstration of high quality single-crystal diamond resonators has led to significant interest in a hybrid system consisting of nitrogen-vacancy center spins that interact with the resonant phonon modes of a macroscopic mechanical resonator through crystal strain. However, the nitrogen-vacancy spin-strain interaction has not been well characterized. Here, we demonstrate dynamic, strain-mediated coupling of the mechanical motion of a diamond cantilever to the spin of an embedded nitrogen-vacancy center. Via quantum control of the spin, we quantitatively characterize the axial and transverse strain sensitivities of the nitrogen-vacancy ground state spin. The nitrogen-vacancy center is an atomic scale sensor and we demonstrate spin-based strain imaging with a strain sensitivity of 3 10^(-6) strain Hz^(-1/2). Finally, we show how this spin-resonator system could enable coherent spin-phonon interactions in the quantum regime.