The force exerted by the gravitational field on a Casimir cavity in terms of Archimedes force of vacuum is discussed, the force that can be tested against observation is identified, and it is shown that the present technology makes it possible to perform the first experimental tests. The use of suitable high-Tc superconductors as modulators of Archimedes force is motivated. The possibility is analyzed of using gravitational wave interferometers as detectors of the force, transported through an optical spring from the Archimedes vacuum force apparatus to the gravitational interferometer test masses to maintain the two systems well separated. The use of balances to actuate and detect the force is also analyzed, the different solutions are compared, and the most important experimental issues are discussed.