We report on broad multi-wavelength observations of the 2010-2011 periastron passage of the gamma-ray loud binary system PSR B1259-63. High resolution interferometric radio observations establish extended radio emission trailing the position of the pulsar. Observations with the Fermi Gamma-ray Space Telescope reveal GeV gamma-ray flaring activity of the system, reaching the spin-down luminosity of the pulsar, around 30 days after periastron. There are no clear signatures of variability at radio, X-ray and TeV energies at the time of the GeV flare. Variability around periastron in the H$alpha$ emission line, can be interpreted as the gravitational interaction between the pulsar and the circumstellar disk. The equivalent width of the H$alpha$ grows from a few days before periastron until a few days later, and decreases again between 18 and 46 days after periastron. In near infrared we observe the similar decrease of the equivalent width of Br$gamma$ line between the 40th and 117th day after the periastron. For the idealized disk, the variability of the H$alpha$ line represents the variability of the mass and size of the disk. We discuss possible physical relations between the state of the disk and GeV emission under assumption that GeV flare is directly related to the decrease of the disk size.
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