We present a study of the plerionic supernova remnant 0540-69.3 in the LMC in X-ray, radio, optical, and infrared. We find that the shell of 0540-69.3 is characterized in the X-ray by thermal nonequilibrium plasma with depleted Mg and Si abundances and a temperature of kT ~ 0.7 keV. This thermal emission is superimposed with synchrotron emission in several regions. Based on X-ray spectra and on morphological considerations in all surveyed wavebands, we conclude that the shell is expanding into a clumpy and highly inhomogeneous medium. In one region of the shell we find an overabundance of Ne, suggesting the presence of ejecta near the edge of the remnant. We also see evidence for reheating of material via a reverse shock originating from the interaction of the supernova blast wave with a particularly dense cloud in the surrounding medium. Finally, we perform the first detailed study of the halo region extending 1.2-2.2 pc from the central pulsar. We detect the presence of thermal and nonthermal spectral components but do not find evidence for mixing or ejecta. We conclude that the thermal component is not a counterpart to similar optical and infrared halos and that it is most likely due to the projection of shell material along the line of sight.