This work demonstrates that a complete description of the interaction of matter and all forces, gravitational and non-gravitational, can in fact be realized within a quantum affine algebraic framework. Using the affine group formalism, we construct elements of a physical Hilbert space for full, Lorentzian quantum gravity coupled to the Standard Model in four spacetime dimensions. Affine algebraic quantization of gravitation and matter on equal footing implies a fundamental uncertainty relation which is predicated upon a non-vanishing cosmological constant.