Let f:X->X be a morphism of a variety over a number field K. We consider local conditions and a Bruaer-Manin condition, defined by Hsia and Silverman, for the orbit of a point P in X(K) to be disjoint from a subvariety V of X, i.e., the intersection of the orbit of P with V is empty. We provide evidence that the dynamical Brauer-Manin condition is sufficient to explain the lack of points in the intersection of the orbit of P with V; this evidence stems from a probabilistic argument as well as unconditional results in the case of etale maps.