Using the Herschel Space Observatorys Heterodyne Instrument for the Far-Infrared (HIFI), we have performed mapping observations of the 620.701 GHz 5(32)-4(41) transition of ortho-H2O within a roughly 1.5 x 1.5 arcmin region encompassing the Kleinmann-Low nebula in Orion, and pointed observations of that transition toward the Orion South condensation and the W49N region of high-mass star formation. Using the Effelsberg 100 m radio telescope, we obtained ancillary observations of the 22.23508 GHz 6(16)-5(23) water maser transition; in the case of Orion-KL, the 621 GHz and 22 GHz observations were carried out within 10 days of each other. The 621 GHz water line emission shows clear evidence for strong maser amplication in all three sources, exhibiting narrow (roughly 1 km/s FWHM) emission features that are coincident (kinematically and/or spatially) with observed 22 GHz features. Moreover, in the case of W49N - for which observations were available at three epochs spanning a two year period - the spectra exhibited variability. The observed 621 GHz/22 GHz line ratios are consistent with a maser pumping model in which the population
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