We prove spectral, stochastic and mean curvature estimates for complete $m$-submanifolds $varphi colon M to N$ of $n$-manifolds with a pole $N$ in terms of the comparison isoperimetric ratio $I_{m}$ and the extrinsic radius $r_varphileq infty$. Our proof holds for the bounded case $r_varphi< infty$, recovering the known results, as well as for the unbounded case $r_{varphi}=infty$. In both cases, the fundamental ingredient in these estimates is the integrability over $(0, r_varphi)$ of the inverse $I_{m}^{-1}$ of the comparison isoperimetric radius. When $r_{varphi}=infty$, this condition is guaranteed if $N$ is highly negatively curved.