We examine the effects of gas expulsion on initially sub-structured and out-of-equilibrium star clusters. We perform N-body simulations of the evolution of star clusters in a static background potential before adjusting that potential to model gas expulsion. We investigate the impact of varying the rate at which the gas is removed, and the instant at which gas removal begins. Reducing the rate at which the gas is expelled results in an increase in cluster survival. Quantitatively, this dependency is approximately in agreement with previous studies, despite their use of smooth, and virialised initial stellar distributions. However, the instant at which gas expulsion occurs is found to have a strong effect on cluster response to gas removal. We find if gas expulsion occurs prior to one crossing time, cluster response is poorly described by any global parameters. Furthermore in real clusters the instant of gas expulsion is poorly constrained. Therefore our results emphasis the highly stochastic and variable response of star clusters to gas expulsion.