The fate of massive stars up to 300 Msun is highly uncertain. Do these objects produce pair-instability explosions, or normal Type Ic supernovae? In order to address these questions, we need to know their mass-loss rates during their lives. Here we present mass-loss predictions for very massive stars (VMS) in the range of 60-300 Msun. We use a novel method that simultaneously predicts the wind terminal velocities (vinf) and mass-loss rate (dM/dt) as a function of the stellar parameters: (i) luminosity/mass Gamma, (ii) metallicity Z, and (iii) effective temperature Teff. Using our results, we evaluate the likely outcomes for the most massive stars.
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