We have studied quantum-well-confined holes based on the Luttinger-model description for the valence band of typical semiconductor materials. Even when only the lowest quasi-two-dimensional (quasi-2D) subband is populated, the static spin susceptibility turns out to be very different from the universal isotropic Lindhard-function lineshape obtained for 2D conduction-electron systems. The strongly anisotropic and peculiarly density-dependent spin-related response of 2D holes at long wavelengths should make it possible to switch between easy-axis and easy-plane magnetization in dilute magnetic quantum wells. An effective g factor for 2D hole systems is proposed.